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Aperio GT 450 DX Scanner

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Overview

Proven Technology for Diagnostic Excellence

Proven technology for improved workflow efficiency and patient care are set to define digital pathology and increase overall adoption. With the call for more rigorous controls, manufacturers of digital pathology devices are being held to the highest standards of quality, security, and patient safety.

The Aperio GT 450 DX uses innovative color calibration technology to output consistent high-quality images enabling on-time, on-screen diagnosis. Aperio GT 450 DX is an automated, high capacity digital pathology slide scanner that offers exceptional image quality, rapid delivery of cases and high-performance streamlined digital viewing built with the pathologist in mind.

  • Improve case turnaround with no touch scanning and continuous loading of the racks directly from the HistoCore SPECTRA Workstation (Stainer & Coverslipper)
  • Increase IT security and control with a dedicated Scanner Administrator Manager DX (SAM DX) server and software that allows you to set up and monitor multiple Aperio GT 450 DX scanners at a time. No more single workstations for each scanner
  • Ensure excellent image quality with Leica optics
Contact Us to get a quote. Call +1 312 565 6737 to speak with a representative.

For In Vitro Diagnostic Use
FDA 510(k) and CE Marked under the IVDR

Confidence in Diagnosis for the Pathologist

The Aperio GT 450 DX starts with quality and stays with quality. High quality digital scans deserve an image management system that detects, stores and delivers whole slide images and metadata exactly where and when needed for confidence in diagnosis.

Aperio GT 450 DX Scanner

  • Designed to rapidly deliver images with exceptional quality for Pathologists.*
  • High performance objective manufactured by Leica Microsystems, renowned for producing world-class optics since 1849.
  • Leica optics deliver exceptional image quality
  • Every slide is calibrated during scanning to ensure the best quality image
  • Automated image quality assessment, so you don’t have to send slides back for re-scans 99.5% accurate tissue finder (H&E stains) finds faint tissue while excluding pen marks, dust, and residue.
Confidence in Diagnosis for the Pathologist

Security and Interoperability for IT Professionals

The Aperio GT 450 DX system offers fast, secure, flexible IT architecture

Aperio GT 450 DX Scanner:

  • HL7, and DICOM compatible for easy integration into LIS, LIMS or PACS
  • A centralize SAM DX server and dedicated software provides you with a data management solution that can remotely set up and monitor multiple Aperio GT 450 DX scanners at a time.
  • Comprehensive cybersecurity including encryption and login controls
  • Centralize scanner management to set up and monitor multiple scanners
  • Scalable set up for hub and spoke configurations
  • Supports dedicated logins for each Aperio GT 450 DX scanner

*VP-0463 validation results

From the lab to the IT room to the office, the Aperio GT 450 DX was designed to scale up digital pathology operations for histotechnicians, IT professionals and pathologists.

Security and Interoperability for IT Professionals

Speed to Quality for Lab Managers and Histotechnicians

The Aperio GT 450 DX is simple to operate and helps lab managers and histotechnicians deliver rapid, quality results with confidence.

Aperio GT 450 DX scanner:

  • No touch continuous loading during scanning
  • Automated IQ checks during each scan to ensure quality
  • Assign priority cases
  • Each slide is calibrated individually prior to scan
  • 450-slide capacity, packed into a small size, fits on the lab bench
  • 99.5% accurate tissue finder (H&E Stains) allows you to adjust if needed*
  • 100% first-time barcode scan success rate*
  • Slides are then automatically scanned at 81 slides per hour at 40x for a 15mm x 15mm area.
  • Fast delivery of urgent cases directly to the pathologist’s viewing station

*VP-0463 validation results

Speed to Quality for Lab Managers and Histotechnicians The Aperio Clinical Solution is simple to operate and helps lab managers and
aperio-gt-450-dx-807x240-new

Image Quality Tested by Pathologists for Pathologists

(for diagnostic review use Aperio Webviewer DX)

Mitotic Events (Breast)
Mitotic Events (Breast)
Intercellular Bridges
Intercellular Bridges
Chromatin
Chromatin
Nucleoli
Nucleoli

Precision, Potential to Scale, and Peace of Mind

Digital pathology scan speeds have not always been fast enough at 40x magnification to keep up with high-volume scanning (120k+ slides per year). Real-Time Focusing (RTF)** offers a potential solution to this problem. It’s a novel method to capture a digital image that combines an imaging line sensor and a focusing line sensor.

  1. While scanning, the focusing line sensor receives focusing data of the tissue.
  2. Proprietary algorithms determine the best focus value.
  3. Then, each best focus value is treated like a control loop with the mechanics, feeding the best focus value to the objective height on the fly.
  4. The positioning adjustments of the objective are performed continuously (in real time) in order to enable the imaging line sensor to capture the image at its best possible focus. Hence, real time focusing.

**US Patent no. 9,841,590

Cellular Groves (Thyroid)
Cellular Groves (Thyroid)

Excellent Image Quality with Custom-Made Leica Objective

The high-performance objectives included with the Aperio GT 450 DX is specifically designed to maximise field of view for high speed digital pathology scanning. Most objectives are designed similarly to the human eye: round, which focuses light in the center and limits field of view. The objectives on the Aperio GT 450 DX includes an extra-wide flat field correction that enables a much larger field of view (1mm) that can accommodate extremely large digital images for fast scans and 0.26 um/pixel resolution at 40x magnification.

Excellent Image Quality with Custom-Made Leica Objective

Downloads

View all available downloads below
Brochure Aperio GT 450 DX 240094 Rev A
Press Release - Aerio GT 450 DX Scanner with DICOM ( 210438-de-Rev. A) Press Release - Aperio GT 450 DX Scanner with DICOM (210438-es-ES-Rev. A) Press Release - Leica Biosystems Enhances Integration of Digital Pathology into the Diagnostic Pathway with DICOM Imaging (210438 Rev A)
Case Study - ASSESSING TIMING AND EFFICIENCY 200658 Rev B White Paper - Real-Time Focusing 200394 Rev B White Paper - Validation Study 220306 Rev B Case Study - Hanna et al 05 DEC 2024 240744 Rev A Case Study - Bauer et al precision 05 DEC 2024 240782 Rev A White Paper - DICOM 3 DEC 2024 240796 Rev B
Aperio eSlide Manager System Requirements - English - MAN-0495-Rev-C Aperio eSlide Manager User Guide - English - MAN-0488-Rev-B Aperio eSlide Manager IT Administrator Guide - English - MAN-0490-Rev-C Aperio GT 450 DX DICOM Upgrade Guide - English - MAN-0515-Rev-B Aperio GT 450 DX Documentation Map - English - MAN-0508-Rev-A Aperio GT 450 DX IT Manager and Lab Administrator Guide - English - MAN-0507-Rev-A Aperio GT 450 DX Quick Reference Guide - English MAN-0514-Rev-A Aperio GT 450 DX Specifications - English MAN-0506-Rev-B Aperio GT 450 DX User Guide - English MAN-0505-Rev-A Aperio LIS Connectivity Overview - English - MAN-0429-Rev-E Aperio WebViewer DX Documentation Map - English - MAN-0494-Rev-A Aperio WebViewer DX IT Administrator Guide - English - MAN-0492-Rev-A Aperio WebViewer DX User Guide - English - MAN-0486-Rev-A
Aperio GT 450 DX User Guide - English MAN-0505-Rev-A Aperio GT 450 DX Specifications - English MAN-0506-Rev-B Aperio GT 450 DX IT Manager and Lab Administrator Guide - English - MAN-0507-Rev-A Aperio GT 450 DX Quick Reference Guide - English MAN-0514-Rev-A Aperio GT 450 DX Documentation Map - English - MAN-0508-Rev-A Aperio GT 450 DX DICOM Upgrade Guide - English - MAN-0515-Rev-B
Aperio GT 450 DX User Guide English MAN-0475 Rev C Aperio GT 450 DX Specifications English MAN-0479 Rev E Aperio GT 450 DX Quick Reference Guide English MAN-0477 Rev C Aperio GT 450 DX IT Manager and Lab Administrator Guide English MAN-0483 Rev C Aperio GT 450 DX Documentation Map English MAN-0498 Rev A
Aperio GT 450 DX User Guide Czech MAN-0475-cs Rev B Aperio GT 450 DX Specifications Czech MAN-0479-cs Rev A Aperio GT 450 DX Quick Reference Guide Czech MAN-0477-cs Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Czech MAN-0483-cs Rev B Aperio GT 450 DX Documentation Map Czech MAN-0498-cs Rev A
Aperio GT 450 DX User Guide Danish MAN-0475-da Rev B Aperio GT 450 DX Specifications Danish MAN-0479-da Rev A Aperio GT 450 DX Quick Reference Guide Danish MAN-0477-da Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Danish MAN-0483-da Rev B Aperio GT 450 DX Documentation Map Danish MAN-0498-da Rev A
Aperio GT 450 DX User Guide Dutch MAN-0475-nl Rev B Aperio GT 450 DX Specifications Dutch MAN-0479-nl Rev A Aperio GT 450 DX Quick Reference Guide Dutch MAN-0477-nl Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Dutch MAN-0483-nl Rev B Aperio GT 450 DX Documentation Map Dutch MAN-0498-nl Rev A
Aperio GT 450 DX User Guide Finnish MAN-0475-fi Rev B Aperio GT 450 DX Specifications Finnish MAN-0479-fi Rev A Aperio GT 450 DX Quick Reference Guide Finnish MAN-0477-fi Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Finnish MAN-0483-fi Rev B Aperio GT 450 DX Documentation Map Finnish MAN-0498-fi Rev A
Aperio GT 450 DX User Guide French MAN-0475-fr Rev C Aperio GT 450 DX Specifications French MAN-0479-fr Rev C-1 Aperio GT 450 DX Quick Reference Guide French MAN-0477-fr Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide French MAN-0483-fr Rev C Aperio GT 450 DX Documentation Map French MAN-0498-fr Rev A
Aperio GT 450 DX User Guide German MAN-0475-de Rev C Aperio GT 450 DX Specifications German MAN-0479-de Rev C-1 Aperio GT 450 DX Quick Reference Guide German MAN-0477-de Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide German MAN-0483-de Rev C Aperio GT 450 DX Documentation Map German MAN-0498-de Rev A
Aperio GT 450 DX User Guide Greek MAN-0475-el Rev B Aperio GT 450 DX Specifications Greek MAN-0479-el Rev A Aperio GT 450 DX Quick Reference Guide Greek MAN-0477-el Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Greek MAN-0483-el Rev B Aperio GT 450 DX Documentation Map Greek MAN-0498-el Rev A
Aperio GT 450 DX User Guide Italian MAN-0475-it Rev C Aperio GT 450 DX Specifications Italian MAN-0479-it Rev C Aperio GT 450 DX Quick Reference Guide Italian MAN-0477-it Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Italian MAN-0483-it Rev C Aperio GT 450 DX Documentation Map Italian MAN-0498-it Rev A
Aperio GT 450 DX User Guide Norwegian MAN-0475-no Rev B Aperio GT 450 DX Specifications Norwegian MAN-0479-no Rev A Aperio GT 450 DX Quick Reference Guide Norwegian MAN-0477-no Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Norwegian MAN-0483-no Rev B Aperio GT 450 DX Documentation Map Norwegian MAN-0498-no Rev A
Aperio GT 450 DX User Guide Polish MAN-0475-pl Rev B Aperio GT 450 DX Specifications Polish MAN-0479-pl Rev A Aperio GT 450 DX Quick Reference Guide Polish MAN-0477-pl Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Polish MAN-0483-pl Rev B Aperio GT 450 DX Documentation Map Polish MAN-0498-pl Rev A
Aperio GT 450 DX User Guide Portuguese-Portugal MAN-0475-pt-PT Rev B Aperio GT 450 DX Specifications Portuguese-Portugal MAN-0479-pt-PT Rev A Aperio GT 450 DX Quick Reference Guide Portuguese-Portugal MAN-0477-pt-PT Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Portuguese-Portugal MAN-0483-pt-PT Rev B Aperio GT 450 DX Documentation Map Portuguese-Portugal MAN-0498-pt-PT Rev A
Aperio GT 450 DX User Guide Russian MAN-0475-ru Rev B Aperio GT 450 DX Specifications Russian MAN-0479-ru Rev A Aperio GT 450 DX Quick Reference Guide Russian MAN-0477-ru Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Russian MAN-0483-ru Rev B Aperio GT 450 DX Documentation Map Russian MAN-0498-ru Rev A
Aperio GT 450 DX User Guide Serbian MAN-0475-sr Rev B Aperio GT 450 DX Specifications Serbian MAN-0479-sr Rev A Aperio GT 450 DX Quick Reference Guide Serbian MAN-0477-sr Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Serbian MAN-0483-sr Rev B Aperio GT 450 DX Documentation Map Serbian MAN-0498-sr Rev A
Aperio GT 450 DX User Guide Slovak MAN-0475-sk Rev B Aperio GT 450 DX Specifications Slovak MAN-0479-sk Rev A Aperio GT 450 DX Quick Reference Guide Slovakian MAN-0477-sk Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Slovak MAN-0483-sk Rev B Aperio GT 450 DX Documentation Map Slovak MAN-0498-sk Rev A
Aperio GT 450 DX User Guide Slovenian MAN-0475-sl Rev B Aperio GT 450 DX Specifications Slovenian MAN-0479-sl Rev A Aperio GT 450 DX Quick Reference Guide Slovenian MAN-0477-sl Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Slovenian MAN-0483-sl Rev B Aperio GT 450 DX Documentation Map Slovenian MAN-0498-sl Rev A
Aperio GT 450 DX User Guide Spanish-Latin-America MAN-0475-es-LA Rev B Aperio GT 450 DX Specifications Spanish-Latin-America MAN-0479-es-LA Rev A Aperio GT 450 DX Quick Reference Guide Spanish-LatinAmerica MAN-0477-es-LA Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Spanish-LatinAmerica MAN-0483-es-LA Rev B Aperio GT 450 DX Documentation Map Spanish-LatinAmerica MAN-0498-es-LA Rev A
Aperio GT 450 DX User Guide Spanish-Spain MAN-0475-es-ES Rev B Aperio GT 450 DX Specifications Spanish-Spain MAN-0479-es-ES Rev A Aperio GT 450 DX Quick Reference Guide Spanish-Spain MAN-0477-es-ES Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Spanish-Spain MAN-0483-es-ES Rev B Aperio GT 450 DX Documentation Map Spanish-Spain MAN-0498-es-ES Rev A
Aperio GT 450 DX User Guide Swedish MAN-0475-sv Rev B Aperio GT 450 DX Specifications Swedish MAN-0479-sv Rev A Aperio GT 450 DX Quick Reference Guide Swedish MAN-0477-sv Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Swedish MAN-0483-sv Rev B Aperio GT 450 DX Documentation Map Swedish MAN-0498-sv Rev A
Aperio GT 450 DX User Guide Turkish MAN-0475-tr Rev B Aperio GT 450 DX Specifications Turkish MAN-0479-tr Rev A Aperio GT 450 DX Quick Reference Guide Turkish MAN-0477-tr Rev A Aperio GT 450 DX IT Manager and Lab Administrator Guide Turkish MAN-0483-tr Rev B Aperio GT 450 DX Documentation Map Turkish MAN-0498-tr Rev A
Aperio GT 450 DX Release 1.2.5 Patch Notice PN-0079-Rev-A Aperio GT 450 DX 1.2.4 Patch Notice PN-0070-Rev-A Aperio GT 450 DX Release 1.2.2 Patch Notice PN-0064-Rev-A Aperio GT 450 DX 1.2 Patch Notice PN-0040-Rev-A Aperio GT 450 DX 1.1.3 Patch Notice - English PN-0038-Rev-A Aperio GT 450 DX 1.1.1 and 1.1.2 Patch Notice - English PN-0035-Rev-A Aperio GT 450 SAM DX Software Versions 1.1 and 1.2 with Windows Server 2022 Patch Notice PN-0054-Rev-A Mirth Connect 4.4.2 Upgrade for Aperio SAM DX Server and Aperio GT 450 DX on Windows Server 20162019 Patch Notice PN-0051-Rev-A

Knowledge Hub

Knowledge Hub Teaser

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Top Considerations When Buying a Digital Pathology Scanner

Are you thinking about purchasing a digital pathology scanner? We offer some tips for things to consider during the buying process.

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Four Tips for Digital Pathology Slide Scanning

Do you want to get better digital images from your glass slides? Here are some tips to help you get the best out of your digital pathology line scanner: